Article
Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species.
Radiation research - 1 Feb 2011
Aykin-Burns Nukhet, Slane Benjamin G, Liu Annie T Y, Owens Kjerstin M, O'Malley Malinda S, Smith Brian J, Domann Frederick E, Spitz Douglas R
Abstract excerpt
It has been hypothesized that ionizing radiation-induced disruptions in mitochondrial O₂ metabolism lead to persistent heritable increases in steady-state levels of intracellular superoxide (O₂(•U+2212)) and hydrogen peroxide (H₂O₂) that contribute to the biological effects of radiation. Hamster fibroblasts (B9 cells) expressing a mutation in the gene coding for the mitochondrial electron transport chain protein...
Topics
- Animals
- Apoptosis
- Cells, Cultured
- Cricetinae
- Cricetulus
- DNA Damage
- Linear Energy Transfer
- Membrane Proteins
- Mitochondria
- Mutation