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Article

Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.

Developmental neuroscience - 1 Jan 2008

Hebbar Sachin, Guillotte Aimee M, Mesngon Mariano T, Zhou Qin, Wynshaw-Boris Anthony, Smith Deanna S

Abstract excerpt

Hemizygous Lis1 mutations cause type 1 lissencephaly, a neuronal migration disorder in humans. The Lis1+/- mouse is a model for lissencephaly; mice exhibit neuronal migration defects but are viable and fertile. On an inbred genetic background, 20% of Lis1+/- mice develop hydrocephalus and die pre...

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Identifiers

PMID: 18075263
DOI: 10.1159/000109860
PMCID: PMC3097246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18075263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.PMID 18075263Read ↗

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