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Article

ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice.

Journal of neurophysiology - 1 Jan 2013

Sebe Joy Y, Bershteyn Marina, Hirotsune Shinji, Wynshaw-Boris Anthony, Baraban Scott C

Abstract excerpt

LIS1 gene mutations lead to a rare neurological disorder, classical lissencephaly, characterized by brain malformations, mental retardation, seizures, and premature death. Mice heterozygous for Lis1 (Lis1(+/-)) exhibit cortical malformations, defects in neuronal migration, increased glutamate-mediated synaptic transmission, and spontaneous electrographic seizures. Recent work demonstrated that in utero treatment...

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Source

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Identifiers

PMID: 23100132
DOI: 10.1152/jn.00431.2012
PMCID: PMC3545457

Genes

CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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