Article
Ranking of genome-wide association scan signals by different measures.
International journal of epidemiology - 1 Oct 2009
Strömberg Ulf, Björk Jonas, Vineis Paolo, Broberg Karin, Zeggini Eleftheria
Abstract excerpt
BACKGROUND: The P-value approach has been employed to prioritizing genome-wide association (GWA) scan signals, with a genome-wide significance defined by a prior P-value threshold, although this is not ideal. A rationale put forward is that the association signals rather should be expected to give less support for single nucleotide polymorphisms (SNPs) that are rare (with associated low-power tests) than for...
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