Article
Reporting and interpretation in genome-wide association studies.
International journal of epidemiology - 1 Jun 2008
Wakefield Jon
Abstract excerpt
BACKGROUND: In the context of genome-wide association studies we critique a number of methods that have been suggested for flagging associations for further investigation. METHODS: The P-value is by far the most commonly used measure, but requires careful calibration when the a priori probability of an association is small, and discards information by not considering the power associated with each test. The...
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