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Article

Application of the optimal discovery procedure to genetic case-control studies: comparison with p values and asymptotic Bayes factors.

Human heredity - 1 Jan 2011

Tachmazidou Ioanna, De Iorio Maria, Dudbridge Frank

Abstract excerpt

OBJECTIVES: The power of genetic association studies is limited by stringent levels of statistical significance. To improve power, Bayes factors (BFs) have been suggested as an alternative measure to the p value, and Storey recently introduced an optimal discovery procedure (ODP) for multiple testing. We aimed to adapt the ODP to genetic case-control studies and to compare its power to p values and asymptotic BFs...

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PMID: 21389730
DOI: 10.1159/000323518

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