Article
Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells.
Neurobiology of disease - 1 Apr 2015
Jiang Luning, O'Leary Claire, Kim Hyun Ah, Parish Clare L, Massalas Jim, Waddington John L, Ehrlich Michelle E, Schütz Günter, Gantois Ilse, Lawrence Andrew J, Drago John
Abstract excerpt
D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human diseases such as Huntington disease and schizophrenia are known to have cortical pathology involving dopamine receptor expressing neurons. To illuminate their functional role, we exploited a Cre/Lox molecular paradigm to generate Emx-1(tox) MUT mice, a transgenic line in which cortical...
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