Article
Impact of amino acid variations in Gag and protease of HIV type 1 CRF01_AE strains on drug susceptibility of virus to protease inhibitors.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2009
Jinnopat Piyamat, Isarangkura-na-ayuthaya Panasda, Utachee Piraporn, Kitagawa Yukiko, de Silva U Chandimal, Siripanyaphinyo Uamporn, Kameoka Yoko, Tokunaga Kenzo, Sawanpanyalert Pathom, Ikuta Kazuyoshi, Auwanit Wattana, Kameoka Masanori
Abstract excerpt
BACKGROUND: Protease (PR) inhibitors (PIs) were designed against subtype B virus of human immunodeficiency virus type 1 (HIV-1), but believed to retain its activity against most of the other subtypes. CRF01_AE PR (AE-PR) contains background mutations that are presumed to alter the drug susceptibility of PR. In addition, amino acid variations found in HIV-1 Gag potentially affect the drug susceptibility or...
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