Article
Sustained appearance of drug resistance-associated mutations in HIV-1 CRF01_AE protease and reverse transcriptase derived from protease inhibitor-naive Thai patients.
The Southeast Asian journal of tropical medicine and public health - 1 Mar 2010
Jullaksorn Duangrat, Boonchawalit Samatchaya, Uttiyoung Jiraporn, Soonthornsata Bongkot, Yowang Amara, Krathong Nongkran, Chautrakul Sununta, Ikuta Kazuyoshi, Roobsoong Amornsak, Kanitvittaya Sangkom, Sawanpanyalert Pathom, Kameoka Masanori
Abstract excerpt
Previous studies revealed that HIV-1 CRF01_AE viruses derived from antiretroviral drug-naïve Thai patients contained several protease (PR) inhibitor (PI) resistance-associated mutations. In this report, we examined the sustained appearance of drug resistance-associated mutations in CRF01_AE PR and reverse transcriptase (RT). Peripheral blood samples were collected every 3 months from April 2008 to April 2009 from...
Topics
- CD4 Lymphocyte Count
- Drug Resistance, Viral
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation