Article
Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency.
American journal of epidemiology - 15 Oct 2009
Castaldi P J, DeMeo D L, Kent D M, Campbell E J, Barker A F, Brantly M L, Eden E, McElvaney N G, Rennard S I, Stocks J M, Stoller J K, Strange C, Turino G, Sandhaus R A, Griffith J L, Silverman E K
Abstract excerpt
Alpha-1-antitrypsin deficiency is a genetic condition associated with severe, early-onset chronic obstructive pulmonary disease (COPD). However, there is significant variability in lung function impairment among persons with the protease inhibitor ZZ genotype. Early identification of persons at highest risk of developing lung disease could be beneficial in guiding monitoring and treatment decisions. Using a...
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