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Article

Lung clearance index for monitoring early lung disease in alpha-1-antitrypsin deficiency.

Respiratory medicine - 1 Jul 2016

Fuchs Susanne I, Schwerk Nicolaus, Pittschieler Klaus, Ahrens Frank, Baden Winfried, Bals Robert, Fähndrich Sebastian, Gleiber Wolfgang, Griese Matthias, Hülskamp Georg, Köhnlein Thomas, Reckling Ludmilla, Rietschel Ernst, Staab Doris, Gappa Monika

Abstract excerpt

Patients with alpha-1-antitrypsin deficiency (AATD) and a PI-ZZ genotype are at high risk to develop severe emphysema during adulthood. However, little is known about early stages of emphysema and disease manifestation in other PI-types. Spirometry is commonly used for monitoring although early manifestation of emphysema is suspected within the peripheral airways that are not accessible by forced expiratory...

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Identifiers

PMID: 27296827
DOI: 10.1016/j.rmed.2016.04.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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