Article
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.
American journal of respiratory cell and molecular biology - 1 Jan 2008
Demeo Dawn L, Campbell Edward J, Barker Alan F, Brantly Mark L, Eden Edward, McElvaney N Gerard, Rennard Stephen I, Sandhaus Robert A, Stocks James M, Stoller James K, Strange Charlie, Turino Gerard, Silverman Edwin K
Abstract excerpt
Severe alpha(1)-antitrypsin (AAT) deficiency is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD), especially in individuals who smoke. There is marked variability in the development of lung disease in individuals homozygous (PI ZZ) for this autosomal recessive condition, suggesting that modifier genes could be important. We hypothesized that genetic determinants of obstructive lung...
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