Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytotoxicity of lymphokine-activated killer cells against human neuroblastoma cells: modulation by neuroblast differentiation.

Medical and pediatric oncology - 1 Jan 1990

Duan D S, Farmer D, Rayner A A, Sadee W

Abstract excerpt

The cytolytic activity of lymphokine-activated killer (LAK) cells against human neuroblastoma (NB) cells was investigated using the continuous NB cell lines, IMR-32, Kelly, and two subclones of SK-N-SH, SH-SY5Y (neuroblastic phenotype), and SH-EP (non-neuronal phenotype). NB cells were found to b...

Topics

Cell Differentiation
Cytotoxicity, Immunologic
Dinoprostone
Humans
Killer Cells, Lymphokine-Activated
Neuroblastoma
Neurotransmitter Agents
Phenotype
Tretinoin
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1972538
DOI: 10.1002/mpo.2950180418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1972538-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytotoxicity of lymphokine-activated killer cells against human neuroblastoma cells: modulation by neuroblast differentiation.PMID 1972538Read ↗

Differentiation‐related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variantsSemantic proximity Read ↗

Autologous tumor-specific cytotoxic T-lymphocytes in a child with neuroblastoma.Semantic proximity Read ↗

The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines.Semantic proximity Read ↗

Retrovirus-mediated gene transfer of the cytokine genes interleukin-1beta and tumor necrosis factor-alpha into human neuroblastoma cells: consequences for cell line behavior and immunomodulatory properties.Semantic proximity Read ↗

The effect of differentiation agents on inflammatory and oxidative responses of the human neuroblastoma cell line SK-N-SH.Semantic proximity Read ↗

Natural interleukin-2 and lymphokine activated killer cells in the treatment of neuroblastoma in vitro and in vivo.Semantic proximity Read ↗

Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity.Semantic proximity Read ↗

Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell linesSemantic proximity Read ↗

Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma.Semantic proximity Read ↗

Effect of culture media on lymphokine-activated killer effector phenotype and lytic capacity.Semantic proximity Read ↗

Lymphokine-activated killer (LAK) cells discriminate between Epstein-Barr virus (EBV)-positive Burkitt's lymphoma cells.Semantic proximity Read ↗

[Cytolytic activity by lymphokines (LAK activity) in chronic myeloid leukemia].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.