Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma.

doi:10.1007/s00262-007-0412-2

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Article

Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma.

Cancer immunology, immunotherapy : CII - 1 May 2008

De Geer Anna, Carlson Lena-Maria, Kogner Per, Levitskaya Jelena

Abstract excerpt

Neuroblastoma (NB) is often described as an unfavorable target for both HLA-restricted and death receptor-mediated elimination by cytotoxic T lymphocytes (CTLs) due to low or absent HLA class I and caspase-8 expression. We investigated the effects of soluble factors released by CTLs activated by TCR triggering (named as activated supernatant; AS) on the levels and composition of cell surface molecules involved in...

Topics

Blotting, Western
Caspase 8
Cell Line, Tumor
Cytokines
Flow Cytometry
Humans
Lymphocyte Activation
Neuroblastoma
Phenotype
Receptors, Death Domain
T-Lymphocytes, Cytotoxic

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Identifiers

PMID: 17962944
DOI: 10.1007/s00262-007-0412-2
PMCID: PMC11031004

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