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Article

Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity.

British journal of cancer - 1 Jun 2004

Airoldi I, Meazza R, Croce M, Di Carlo E, Piazza T, Cocco C, D'Antuono T, Pistoia V, Ferrini S, Corrias M V

Abstract excerpt

Interferon-gamma (IFN-gamma) directs T helper-1 cell differentiation and mediates antitumour effects in preclinical models. However, high-dose IFN-gamma is toxic in vivo, and IFN-gamma-transfected neuroblastoma (NB) cells secreting high amounts of the cytokine may be lost due to cell apoptosis or differentiation. Two human NB cell lines (ACN and SK-N-BE2(c)) differing as to genetic and phenotypic features were...

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Identifiers

PMID: 15150552
DOI: 10.1038/sj.bjc.6601842
PMCID: PMC2409504

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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