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Article

Cross-species RNAi rescue platform in Drosophila melanogaster.

Genetics - 1 Nov 2009

Kondo Shu, Booker Matthew, Perrimon Norbert

Abstract excerpt

RNAi-mediated gene knockdown in Drosophila melanogaster is a powerful method to analyze loss-of-function phenotypes both in cell culture and in vivo. However, it has also become clear that false positives caused by off-target effects are prevalent, requiring careful validation of RNAi-induced phenotypes. The most rigorous proof that an RNAi-induced phenotype is due to loss of its intended target is to rescue the...

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Identifiers

PMID: 19720858
DOI: 10.1534/genetics.109.106567
PMCID: PMC2778968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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