Article
Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid.
FEBS letters - 6 Oct 2009
Takahashi Tadanobu, Hashimoto Asako, Maruyama Mami, Ishida Hideharu, Kiso Makoto, Kawaoka Yoshihiro, Suzuki Yasuo, Suzuki Takashi
Abstract excerpt
To identify a determinant of human H3 hemagglutinin (HA) amino acid residues linked to the recognition of molecular species of sialic acid, we generated six mutant viruses possessing either the wild-type HA gene from A/Memphis/1/71 (H3N2) or a genetically single-mutated HA gene at position 137, 144, 155, 158 or 193 from a genetic backbone of A/WSN/33 (H1N1) by reverse genetics. We evaluated the binding ability...
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