Structural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT.

Abstract excerpt

Major facilitators represent the largest superfamily of secondary active transporter proteins and catalyze the transport of an enormous variety of small solute molecules across biological membranes. However, individual superfamily members, although they may be architecturally similar, exhibit strict specificity toward the substrates they transport. The structural basis of this specificity is poorly understood. A...

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