Exploration of key residues and conformational change of anti-terminator protein GlpP for ligand and RNA binding.

doi:10.1002/prot.26045

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Article

Exploration of key residues and conformational change of anti-terminator protein GlpP for ligand and RNA binding.

Proteins - 1 Jun 2021

Chen Qiaoqing, Cui Wenjing, Zhou Zhemin, Han Laichuang

Abstract excerpt

Anti-terminator protein GlpP regulates gene expression of glycerol uptake operon at post-transcriptional level in a number of bacteria. By now, the molecular dynamics details of ligand and RNA binding by GlpP are still obscure. In this study, we employed the molecular dynamic (MD) simulation and constructed a functional verification platform of GlpP to resolve these puzzles. By combining molecular docking, MD...

Topics

Bacillus subtilis
Bacterial Proteins
Binding Sites
Cloning, Molecular
Crystallography, X-Ray
Escherichia coli
Gene Expression
Gene Expression Regulation, Bacterial
Genetic Vectors
Glycerophosphates
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Engineering

Models, Molecular

Molecular Docking Simulation

Molecular Dynamics Simulation

Mutation

Protein Binding

Protein Conformation, alpha-Helical

Source

Open in PubMed

Identifiers

PMID: 33455022
DOI: 10.1002/prot.26045

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