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Article

Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family.

Journal of synchrotron radiation - 1 Jan 2004

Lee John K, Khademi Shahram, Harries William, Savage David, Miercke Larry, Stroud Robert M

Abstract excerpt

The 2.2 A resolution crystal structure of GlpF, an E. coli aquaporin that facilitates the flow of glycerol, water and other small solutes, provides much insight into the molecular function and selectivity of aquaporins. Using GlpF and its atomic structure as a paradigm for the ten highly conserved human aquaporins, site-directed mutagenesis has been used to mutate residues that are possibly integral to the...

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Source

Identifiers

PMID: 14646142
DOI: 10.1107/s0909049503023872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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