Article
Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation.
Biochemistry - 20 Aug 2013
Modi Niraj, Bárcena-Uribarri Iván, Bains Manjeet, Benz Roland, Hancock Robert E W, Kleinekathöfer Ulrich
Abstract excerpt
The outer membrane porin OprP of Pseudomonas aeruginosa forms a highly specific phosphate selective channel. This channel is responsible for the high-affinity uptake of phosphate ions into the periplasmic space of the bacteria. A detailed investigation of the structure-function relationship of OprP is inevitable to decipher the anion and phosphate selectivity of this porin in particular and to broaden the present...
Topics
- Amino Acid Sequence
- Arginine
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Binding Sites
- Binding, Competitive
- Ion Channel Gating
- Ion Transport
- Lipid Bilayers
- Membrane Potentials