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Article

Dicer is required for proper liver zonation

27 Jul 2009

Abstract excerpt

A number of genes and their protein products are expressed within the liver lobules in a region-specific manner and confer heterogeneous metabolic properties to hepatocytes; this phenomenon is known as 'metabolic zonation'. To elucidate the roles of Dicer, an endoribonuclease III type enzyme required for microRNA biogenesis, in the establishment of liver zonation, we examined the distribution of proteins...

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PMID: 19718708
DOI: 10.1002/path.2606

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