Article
Inhibition of T cell development in thymic organ culture: implications for the mechanism of action of cyclosporin A.
European journal of immunology - 1 Apr 1990
Siegel R M, Yui K, Tenenholz D E, Kubo R, Greene M I
Abstract excerpt
We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of T cells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of alpha/beta TcR/CD3 complexes and a mature phen...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4-Positive T-Lymphocytes
- Cyclosporins
- Female
- Histocompatibility Antigens Class II
- Interleukins
- Mice
- Mice, Inbred C57BL
- Organ Culture Techniques
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- T-Lymphocytes, Regulatory