Effects of cyclosporin on C57BL/6 splenocytes before and after culture with high-dose recombinant interleukin-2: implications for immunosuppression with cyclosporin.

doi:10.1007/BF01740940

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Article

Effects of cyclosporin on C57BL/6 splenocytes before and after culture with high-dose recombinant interleukin-2: implications for immunosuppression with cyclosporin.

Cancer immunology, immunotherapy : CII - 1 Jan 1990

Sutherland F, Borkenhagen K, Temple L, Bryant L D, Lafreniere R

Abstract excerpt

Lymphokine-activated killer cells appear to arise from precursor cells bearing natural killer (NK) cell antigens. Cyclosporin (CsA) is a well-known immunosuppressive agent that can down-regulate NK cell cytotoxicity. Studies were initiated to evaluate the effects of CsA on splenocytes before and after exposure to recombinant interleukin-2 (rIL-2). Normal C57BL/6 mice receiving CsA at a dose of 100 mg/kg...

Topics

Animals
Cell Cycle
Cell Division
Cell Survival
Cells, Cultured
Cyclosporins
Dose-Response Relationship, Drug
Down-Regulation
Female
Injections, Intraperitoneal
Interleukin-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interphase

Killer Cells, Natural

Mice

Mice, Inbred Strains

Phenotype

Recombinant Proteins

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 2376049
DOI: 10.1007/BF01740940
PMCID: PMC11038929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2376049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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