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Article

Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992

Bishop D K, Li W

Abstract excerpt

Modified limiting dilution analysis techniques were used to evaluate the effects of the immunosuppressants cyclosporin A (CsA) and FK506 on alloantigen-induced T cell activation in vivo. Treatment of sponge matrix allograft recipients with either CsA or FK506 inhibited lymphocytic infiltration of the allograft, a process thought to be dependent on local lymphokine production. In addition, both immunosuppressants...

Topics

Animals
CD4 Antigens
CD8 Antigens
Cyclosporine
Female
Interleukin-2
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Phenotype
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Helper-Inducer

Tacrolimus

Transplantation, Homologous

Source

Identifiers

PMID: 1371128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371128-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo.PMID 1371128Read ↗

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