Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1992

Bishop D K, Li W

Abstract excerpt

Modified limiting dilution analysis techniques were used to evaluate the effects of the immunosuppressants cyclosporin A (CsA) and FK506 on alloantigen-induced T cell activation in vivo. Treatment of sponge matrix allograft recipients with either CsA or FK506 inhibited lymphocytic infiltration of the allograft, a process thought to be dependent on local lymphokine production. In addition, both immunosuppressants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Antigens
Share to Interleukin-2
Share to Lymphocyte Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Inbred DBA

Share to Phenotype

Share to T-Lymphocytes

Source

Identifiers

PMID: 1371128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo.PMID 1371128Read ↗

The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: an in vivo preliminary study.Semantic proximity Read ↗

Blockade of interleukin-2 production from cloned T cells by cyclosporine and FK 506 assessed by proliferation assays in vitro.Semantic proximity Read ↗

Effects of cyclosporin on C57BL/6 splenocytes before and after culture with high-dose recombinant interleukin-2: implications for immunosuppression with cyclosporin.Semantic proximity Read ↗

Thromboxane augmentation of alloreactive T cell function.Semantic proximity Read ↗

Inhibition of T cell development in thymic organ culture: implications for the mechanism of action of cyclosporin A.Semantic proximity Read ↗

Evidence that cyclosporine treatment causes the appearance in rat lymph node of T cells having the antigenic phenotypes of cortical thymocytes.Semantic proximity Read ↗

Understanding the alloresponse: New approaches to graft-versus-host disease preventionSemantic proximity Read ↗

High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.