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Article

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.

Behavioural brain research - 5 Jan 2010

Ibi Daisuke, Nagai Taku, Koike Hiroyuki, Kitahara Yuko, Mizoguchi Hiroyuki, Niwa Minae, Jaaro-Peled Hanna, Nitta Atsumi, Yoneda Yukio, Nabeshima Toshitaka, Sawa Akira, Yamada Kiyofumi

Abstract excerpt

Gene-environment interaction may play a role in the etiology of schizophrenia. Transgenic mice expressing dominant-negative DISC1 (DN-DISC1 mice) show some histological and behavioral endophenotypes relevant to schizophrenia. Viral infection during neurodevelopment provides a major environmental risk for schizophrenia. Neonatal injection of polyriboinosinic-polyribocytidylic acid (polyI:C), which mimics innate...

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Source

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Identifiers

PMID: 19716847
DOI: 10.1016/j.bbr.2009.08.027
PMCID: PMC2846597

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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