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Article

SIRT1 markedly extends replicative lifespan if the NAD<sup>+</sup> salvage pathway is enhanced

28 Aug 2009

Abstract excerpt

Sir2 mediates lifespan extension in lower eukaryotes but whether its mammalian homolog, sirtuin 1, silent mating type information regulation 2 homolog (SIRT1), is a longevity protein is controversial. We stably introduced the SIRT1 gene into human vascular smooth muscle cells (SMCs) and observed minimal extension of replicative lifespan. However, SIRT1 activity was found to be exquisitely dependent on...

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PMID: 19716821
DOI: 10.1016/j.febslet.2009.08.031

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