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Article

Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep.

Reproduction (Cambridge, England) - 1 Dec 2009

Nicol Linda, Bishop Stephen C, Pong-Wong Ricardo, Bendixen Christian, Holm Lars-Erik, Rhind Stewart M, McNeilly Alan S

Abstract excerpt

The control of fecundity is critical in determining mammalian offspring survival. It is regulated principally by the ovulation rate, so that primates and large farm species commonly have a single offspring. Previously, several mutations have been identified in sheep which increase the naturally low ovulation rate; although in some cases homozygous ewes are infertile. In the present study we present a detailed...

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Share to Chromosomes, Mammalian
Share to Growth Differentiation Factor 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Female

Share to Mutation, Missense

Share to Oocytes

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Share to Sheep Diseases

Source

Identifiers

PMID: 19713444
DOI: 10.1530/REP-09-0193

Genes

GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep.PMID 19713444Read ↗

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