Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozygous ewes and causes infertility in homozygous ewes.

Animal genetics - 1 Oct 2014

Souza C J H, McNeilly A S, Benavides M V, Melo E O, Moraes J C F

Abstract excerpt

Litter size (LS) in sheep is determined mainly by ovulation rate (OR). Several polymorphisms have been identified in the growth differentiation factor 9 (GDF9) gene that result in an increase in OR and prolificacy of sheep. Screening the databank of the Brazilian Sheep Breeders Association for triplet delivery, we identified flocks of prolific Ile de France ewes. After resequencing of GDF9, a point mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 15
Share to Breeding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Growth Differentiation Factor 9

Share to Infertility

Share to Litter Size

Share to Ovarian Follicle

Share to Ovulation

Source

Identifiers

PMID: 25039891
DOI: 10.1111/age.12190

Genes

GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozygous ewes and causes infertility in homozygous ewes.PMID 25039891Read ↗

Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep.Semantic proximity Read ↗

Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).Semantic proximity Read ↗

Influence of FecGE mutation on the reproductive variables of Pelibuey ewes in the anestrus period.Semantic proximity Read ↗

Direct evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of Finnsheep.Semantic proximity Read ↗

A frameshift deletion in the GDF9 gene in Icelandic Loa prolific sheep.Semantic proximity Read ↗

Identification of point mutations in exon 2 of GDF9 gene in Kermani sheep.Semantic proximity Read ↗

Polymorphism study of growth differentiation factor 9B (GDF9B) gene and its association with reproductive traits in sheep.Semantic proximity Read ↗

Association of missense variants in GDF9 with litter size in Entlebucher Mountain dogs.Semantic proximity Read ↗

Screening for Causative Mutations of Major Prolificacy Genes in Iranian Fat-Tailed Sheep.Semantic proximity Read ↗

Genetic regulation of ovulation rate and multiple birthsSemantic proximity Read ↗

A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep.Semantic proximity Read ↗

Genetic polymorphism of growth differentiation factor 9 (GDF9) gene related to fecundity in two Egyptian sheep breeds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.