Article
Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women.
Human reproduction (Oxford, England) - 1 Sept 2013
Wang Ting-Ting, Ke Zhang-Hong, Song Yang, Chen Lu-Ting, Chen Xi-Jing, Feng Chun, Zhang Dan, Zhang Run-Ju, Wu Yan-Ting, Zhang Yu, Sheng Jian-Zhong, Huang He-Feng
Abstract excerpt
STUDY QUESTION: Do any mutations in growth differentiation factor 9 (GDF9) have a role in diminished ovarian reserve (DOR) in young women? SUMMARY ANSWER: The GDF9 p.R146C mutation may be a source of DOR in some young women. WHAT IS KNOWN ALREADY: DOR affects 10% of women under 37 years of age and is associated with accelerated expenditure of follicles. GDF9 is an oocyte-secreted factor that plays a critical role...
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