Article
The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology.
Reproduction (Cambridge, England) - 1 Oct 2004
McNatty K P, Moore L G, Hudson N L, Quirke L D, Lawrence S B, Reader K, Hanrahan J P, Smith P, Groome N P, Laitinen M, Ritvos O, Juengel J L
Abstract excerpt
Ovulation rate in mammals is determined by a complex exchange of hormonal signals between the pituitary gland and the ovary and by a localised exchange of hormones within ovarian follicles between the oocyte and its adjacent somatic cells. From examination of inherited patterns of ovulation rate in sheep, point mutations have been identified in two oocyte-expressed genes, BMP15 (GDF9B) and GDF9. Animals...
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