Article
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice.
The Journal of infectious diseases - 15 Jan 2006
Delahaye Nicolas F, Coltel Nicolas, Puthier Denis, Flori Laurence, Houlgatte Remi, Iraqi Fuad A, Nguyen Catherine, Grau Georges E, Rihet Pascal
Abstract excerpt
The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA microarrays. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified...
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