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Article

HIPK4 is essential for murine spermiogenesis.

eLife - 12 Mar 2020

Crapster J Aaron, Rack Paul G, Hellmann Zane J, Le Austen D, Adams Christopher M, Leib Ryan D, Elias Joshua E, Perrino John, Behr Barry, Li Yanfeng, Lin Jennifer, Zeng Hong, Chen James K

Abstract excerpt

Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that homeodomain-interacting protein kinase 4 (HIPK4) is essential for spermiogenesis and male fertility in mice. HIPK4 is predominantly expressed in round and early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32163033
DOI: 10.7554/eLife.50209
PMCID: PMC7067585

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