Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene

20 Apr 2017

Abstract excerpt

The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that subjects harboring mutations in the NGLY1 gene exhibited severe systemic symptoms (NGLY1-deficiency). While the enzyme obviously has a critical role in mammals, its precise function remains unclear. In this study, we analyzed Ngly1-deficient mice and found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Glycosylation and Glycoproteins Research
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28426790
DOI: 10.1371/journal.pgen.1006696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase genePMID 28426790Read ↗

Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells.Semantic proximity Read ↗

Cytosolic Peptide: N-Glycanase (NGLY1)-from Basic Biology to Genetic Disorder, NGLY1 Deficiency.Semantic proximity Read ↗

NGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology.Semantic proximity Read ↗

Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress.Semantic proximity Read ↗

Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems.Semantic proximity Read ↗

Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency.Semantic proximity Read ↗

The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functions.Semantic proximity Read ↗

Progressive Neurodegeneration, Motor Decline, and Premature Mortality in Aging Ngly1 Deficient RatsSemantic proximity Read ↗

Peptide: N-Glycanase 1 and Its Relationship with Congenital Disorder of DeglycosylationSemantic proximity Read ↗

NGLY1: A fascinating, multifunctional molecule.Semantic proximity Read ↗

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency.Semantic proximity Read ↗

Unexplained death in patients with NGLY1 mutations may be explained by adrenal insufficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.