Article
Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro.
Journal of virology - 1 Aug 2002
Maguire Michael F, Guinea Rosario, Griffin Philip, Macmanus Sarah, Elston Robert C, Wolfram Josie, Richards Naomi, Hanlon Mary H, Porter David J T, Wrin Terri, Parkin Neil, Tisdale Margaret, Furfine Eric, Petropoulos Chris, Snowden B Wendy, Kleim Jörg-Peter
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) Gag protease cleavage sites (CS) undergo sequence changes during the development of resistance to several protease inhibitors (PIs). We have analyzed the association of sequence variation at the p7/p1 and p1/p6 CS in conjunction with amprenavir (APV)-specific protease mutations following PI combination therapy with APV. Querying a central resistance data repository...
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