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Article

Targeting a bacterial stress response to enhance antibiotic action.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Lee Samuel, Hinz Aaron, Bauerle Elizabeth, Angermeyer Angus, Juhaszova Katy, Kaneko Yukihiro, Singh Pradeep K, Manoil Colin

Abstract excerpt

This report describes the identification and analysis of a 2-component regulator of Pseudomonas aeruginosa that is a potential aminoglycoside antibiotic combination therapy target. The regulator, AmgRS, was identified in a screen of a comprehensive, defined transposon mutant library for functions whose inactivation increased tobramycin sensitivity. AmgRS mutations enhanced aminoglycoside action against bacteria...

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Share to Aminoglycosides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Mutagenesis, Insertional

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Source

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Identifiers

PMID: 19706543
DOI: 10.1073/pnas.0903619106
PMCID: PMC2732827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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