Article
Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor.
Cell reports - 21 Feb 2013
Ogembo Javier G, Kannan Lakshmi, Ghiran Ionita, Nicholson-Weller Anne, Finberg Robert W, Tsokos George C, Fingeroth Joyce D
Abstract excerpt
Epstein-Barr virus (EBV) attachment to primary B cells initiates virus entry. Although CD21 is the only known receptor for EBVgp350/220, a recent report documents EBV-infected B cells from a patient genetically deficient in CD21. On normal resting B cells, CD21 forms two membrane complexes: one with CD19 and another with CD35. Whereas the CD21/CD19 complex is widely retained on immortalized and B cell tumor...
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