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Article

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

12 Aug 2009

Abstract excerpt

Approximately 50% of cancer patients receive radiation treatment, either alone or in combination with other therapies. Tumor hypoxia has long been associated with resistance to radiation therapy. Moreover, the expression of hypoxia inducible factors HIF1alpha and/or HIF2alpha correlates with poor prognosis in many tumors. Recent evidence indicates that HIF1alpha expression can enhance radiation-induced apoptosis...

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PMID: 19706526
DOI: 10.1073/pnas.0907357106

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