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Article

An Essential Role of the HIF‐1α–c‐Myc Axis in Malignant Progression

1 Oct 2009

Abstract excerpt

Cancer is a disease of genomic aberration. The hypoxic microenvironment is believed to promote tumor progression via the induction of genetic instability. To understand how hypoxia drives tumor progression, we have shown recently that the hypoxia-inducible transcription factor, HIF-1alpha, is critical for transcriptional repression of DNA repair genes by a noncanonical mode of action referred to as the...

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PMID: 19845622
DOI: 10.1111/j.1749-6632.2009.05043.x

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