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Article

Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB.

PloS one - 10 Aug 2010

Rohwer Nadine, Dame Christof, Haugstetter Anja, Wiedenmann Bertram, Detjen Katharina, Schmitt Clemens A, Cramer Thorsten

Abstract excerpt

BACKGROUND: Reduced chemosensitivity of solid cancer cells represents a pivotal obstacle in clinical oncology. Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy. The hypoxia-inducible factor HIF-1alpha has been linked to chemosensitivity while the underlying molecular mechanisms remain largely elusive. Therefore, we comprehensively...

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Identifiers

PMID: 20706634
DOI: 10.1371/journal.pone.0012038
PMCID: PMC2919384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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