Article
Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.
Molecular and biochemical parasitology - 1 Sept 2000
Fidock D A, Nomura T, Cooper R A, Su X, Talley A K, Wellems T E
Abstract excerpt
The determinant of chloroquine resistance (CQR) in a Plasmodium falciparum cross was previously mapped by linkage analysis to a 36 kb segment of chromosome 7. Candidate genes within this segment have been previously shown to include two genes, cg2 and cg1, that have complex polymorphisms linked t...
Topics
- Alleles
- Animals
- Antimalarials
- Chloroquine
- Drug Resistance
- Genes, Protozoan
- Humans
- Malaria
- Parasitic Sensitivity Tests
- Plasmodium falciparum
- Polymorphism, Genetic
- Protozoan Proteins
- Recombination, Genetic
- Transfection
- Transformation, Genetic