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Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

20 Sept 2019

Abstract excerpt

Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs. Understanding the basis of P. vivax chloroquine resistance (CQR) will inform drug discovery and malaria control. Here we investigate the genetics of...

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PMID: 31541097
DOI: 10.1038/s41467-019-12256-9

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