Article
[Detection of cells with phenotype of multiple drug resistance in myeloproliferative disorders before the treatment].
Gematologiia i transfuziologiia - 1 Feb 1990
Kemnitz J, Freund M, Diminis M, Cohnert T, Uysal A, Georgii A
Abstract excerpt
The expression of the multidrug resistance (MDR) phenotype is connected with the overexpression of P-glycoprotein. By applying the immunocytochemical assay we have demonstrated that in myeloproliferative diseases (AML, ALL, MDS, CGL), in single cases, in smear preparations from the peripheral blood and bone marrow the cells with MDR-positive phenotype can be detected in the material obtained from patients before...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Bone Marrow
- Humans
- Immunoblotting
- Immunosuppressive Agents
- Membrane Glycoproteins
- Myeloproliferative Disorders
- Phenotype
- Receptors, Drug