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Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

24 Aug 2009

Abstract excerpt

Recent evidence suggests the Akt-mTOR pathway may play a role in development of low-grade gliomas (LGG). We sought to evaluate whether activation of this pathway correlates with survival in LGG by examining expression patterns of proteins within this pathway. Forty-five LGG tumor specimens from newly diagnosed patients were analyzed for methylation of the putative 5'-promoter region of PTEN using...

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PMID: 19705067
DOI: 10.1007/s11060-009-0004-4

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