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Article

Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine.

Infection and immunity - 1 Nov 2009

Subashchandrabose Sargurunathan, LeVeque Rhiannon M, Wagner Trevor K, Kirkwood Roy N, Kiupel Matti, Mulks Martha H

Abstract excerpt

In Actinobacillus pleuropneumoniae, which causes porcine pleuropneumonia, ilvI was identified as an in vivo-induced (ivi) gene and encodes the enzyme acetohydroxyacid synthase (AHAS) required for branched-chain amino acid (BCAA) biosynthesis. ilvI and 7 of 32 additional ivi promoters were upregulated in vitro when grown in chemically defined medium (CDM) lacking BCAA. Based on these observations, we hypothesized...

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Identifiers

PMID: 19703979
DOI: 10.1128/IAI.00671-09
PMCID: PMC2772520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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