Article
The branched-chain amino acid aminotransferase encoded by ilvE is involved in acid tolerance in Streptococcus mutans.
Journal of bacteriology - 1 Apr 2012
Santiago Brendaliz, MacGilvray Matthew, Faustoferri Roberta C, Quivey Robert G
Abstract excerpt
The ability of Streptococcus mutans to produce and tolerate organic acids from carbohydrate metabolism represents a major virulence factor responsible for the formation of carious lesions. Pyruvate is a key metabolic intermediate that, when rerouted to other metabolic pathways such as amino acid biosynthesis, results in the alleviation of acid stress by reducing acid end products and aiding in maintenance of...
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