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Article

Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence.

PloS one - 1 Jan 2017

Xie Fang, Li Gang, Wang Yalei, Zhang Yanhe, Zhou Long, Wang Chengcheng, Liu Shuanghong, Liu Siguo, Wang Chunlai

Abstract excerpt

Pyridoxal 5'-phosphate (PLP) is an essential cofactor for numerous enzymes involved in a diversity of cellular processes in living organisms. Previous analysis of the Actinobacillus pleuropneumoniae S-8 genome sequence revealed the presence of pdxS and pdxT genes, which are implicated in deoxyxylulose 5-phosphate (DXP)-independent pathway of PLP biosynthesis; however, little is known about their roles in A....

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PMID: 28448619
DOI: 10.1371/journal.pone.0176374
PMCID: PMC5407770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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