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Article

The intestinal fatty acid propionate inhibits <i><scp>S</scp>almonella</i> invasion through the post‐translational control of <scp><scp>HilD</scp></scp>

4 Jan 2013

Abstract excerpt

To cause disease, Salmonella must invade the intestinal epithelium employing genes encoded within Salmonella Pathogenicity Island 1 (SPI1). We show here that propionate, a fatty acid abundant in the intestine of animals, repressed SPI1 at physiologically relevant concentration and pH, reducing expression of SPI1 transcriptional regulators and consequently decreasing expression and secretion of effector proteins,...

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PMID: 23289537
DOI: 10.1111/mmi.12149

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