Article
Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population.
Transfusion - 1 Nov 2009
Picard Chistophe, Frassati Coralie, Basire Agnes, Buhler Stephan, Galicher Vital, Ferrera Virginie, Reviron Denis, Zappitelli Jean-Pierre, Bailly Pascal, Chiaroni Jacques
Abstract excerpt
BACKGROUND: Anti-Fy(a) has been implicated in hemolytic transfusion reactions. However, not all Fy(a-) patients develop anti-Fy(a) after transfusion with 1 unit of blood [Fy(a+)]. This study was designed to identify HLA-DRB1 alleles associated with a predisposition to Fy(a) immunization after blood transfusion. STUDY DESIGN AND METHODS: To identify HLA-DRB1 alleles prone to immunization after blood transfusion or...
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