Article
Association between HLA-DRB1*01 and HLA-DRB1*15 with alloimmunisation in transfusion-dependent patients with thalassaemia.
Transfusion medicine (Oxford, England) - 1 Aug 2020
Ebrahimi Mina, Dayer Dian, Jalalifar Mohammad Ali, Keikhaei Bijan, Tahan Nejad Asadi Zari
Abstract excerpt
BACKGROUND: Alloantibody production is one of the most challenging complications in transfusion-dependent thalassaemia patients. Haemolytic anaemia, an increase in blood consumption, difficulty in haematopoietic stem cell transplantation and reduced quality of life are consequences of alloimmunisation. The most predisposed antigens (Ags) for alloantibody development are Rh and Kell blood group Ags. OBJECTIVE: The...
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